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Clinical studies on pyridoxine in relation to neurological effects (see Table 2 for individual/anecdotal evidence) Duration Dosage Authors Subjects Number of Findings Conclusions (mg/day) treatment No adjustments in distal Patients with motor Duration too Del Tredici et al carpal tunnel 24 a hundred and fifty or 300 4 months latency or quick to evaluate (1985) syndrome self-assesneurological effects sment questionnairethe situation could also be due to pyridoxine de Ellis et al Patients with No adverse ciency; typical treatment (1979) (and carpal tunnel 35 100-300 up to 12 neurologischedule of 12 weeks studies cited); syndrome weeks cal effects (Ellis, 1987) is of too quick Ellis (1987) reported length to access neurological results Patients with No assessDuration too Kerr (1977) premenstrual 70 40-100 2 months ment of side short to assess syndrome results neurological results No neurological comSmall group measurement however plications in very prolonged duration; Patients with 22 patients inuence of the or nerve Mitwalli et al hyperoxaluria 22 250-500 1-6 years conduction illness on (1984) (kidney abnormapyridoxine dealing with, stones) requirements and lities in 7 patients neurological response are not identified studied intimately Small group measurement however very No abnorextended duration; the malities of absence of effects at Patients with motor or doses equal to 10-90 Mpofu et al homocystei17 200-500 10-24 years sensory mg/kg/day suggests that (1991) nuria nerve these sufferers could show conduction decreased responsiveness velocities to the neuronal antagonistic effects of pyridoxine Pauling (1984) Undened >5000 200 not given No particulars No details out there; cites Hawkins patients cannot be assessed No assesResults from a survey Pullon et al Women 410 not described not described sments of of 1826 women; no (1989) potential data on tolerability neuropathy and unwanted side effects No results Small variety of subjects and very restricted Tolis et al Women 9 200 or 400 2 months on growth duration of remedy; (1977) hormone or no assessment of prolactin neurological results No distinction in Women with unwanted effects Duration too Williams et al premenstrual 204 (out one hundred 3 months between short to access (1985) syndrome of 434) therapies neurological effects and placebo teams Data evaluation for A systematic evaluation of printed and Women with reports of unpublished Wyatt et al premenstrual 526 (out 50-600 up to four side effects; randomised (1999) syndrome of 910) months 1 reported placebo controlled case of trials; all research of neurological inadequate period unwanted effects 37 europa. 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